Shape Analysis of Human Brain with Cognitive Disorders

In this paper, we present some of our current studies on how human brain structures are influenced by cognitive disorders occurred from various neurological and psychiatric diseases based on magnetic resonance imaging (MRI). We first give a brief introduction about computational neuroanatomy, which is the basis of these studies. In Section 2, several novel methods on segmentations of brain tissue and anatomical substructures were presented. Section 3 presented some studies on brain image registration, which plays a core role in computational neuroanatomy. Shape analysis of substructures, cerebral cortical thickness and complexity was presented in Section 4. Finally, some prospects and future research directions in this field are also given.